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A simple and efficient approach to the synthesis of β-N-methylamino-L-alanine (BMAA)


A novel, efficient and straightforward synthesis of β-N-methylamino-L-alanine (BMAA) in two steps starting from L-N,N-dibenzylserine benzyl ester is described. This method, in the light of other syntheses of BMAA, provides benefits such as mild reaction conditions, a simple work-up procedure, good yields and the retention of the serine stereochemistry.

Enzo B. Arévalo-García and Juan Carlos Colmenares Q. Tetrahedron Letters, 55 (2014) 2335 – 2336


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